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Hpv As The Risk Factor Of Oral/Oropharyngeal Cancer

Klozar J., Betka J., Smahelova J., Ludvikova V., Hamsikova E., Tachezy R.

Background: Human papillomaviruses (HPV) are the main etiological factor of cervical carcinoma and are also considered as a possible etiological factor of other tumors including oral/oropharyngeal cancer. The aim of our study was to detect the prevalence of HPV in oral/oropharyngeal carcinomas and to compare the results with clinical characteristics of the tumor and of the patient population. Methods: Patients with oral/oropharyngeal carcinoma operated in the Dept. of Otolaryngology Head and Neck Surgery, Prague in the period of 2001-2004 have been enrolled in our study. All patients signed the information consent forms and filled up detailed risk factor questionnaires. A tissue from all patients treated surgically was analyzed histologically. HPV DNA detection was done by means of polymerase chain reaction (PCR) with general GP5+/GP6+ primers in DNA extracted from a paraffin embedded tumor tissues. Results: So far, 110 patients have enrolled in our study and we have evaluted 68 of them. HPV DNA was detected in 51.5% of samples tested. Among the HPV DNA positive tumours, 80% contained HPV16. In the analyzed group there were 54 men and 14 women. The prevalence of HPV DNA was lower in oral (25%) than in oropharyngeal (57%) tumours, and higher in never smokers (100%) and never drinkers (68.8%). HPV DNA presence was not related to gender, age, number of lifetime sexual partners or practice of oral-genital sex, size of tumour or presence of regional metastases. Conclusions: The difference in the prevalence of HPV DNA positive tumours between cases of oral cavity and oropharyngeal carcinoma exposed and not exposed to tobacco or alcohol support the theory that HPV DNA positive tumours form an etiologically distinct subgroup of head and neck tumours. The study was supported by grant NR/8426-3, Internal Grant Agency of the Czech Ministry of Health

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